MovDisordV3, Main, Exploration, bibRecord, 002073

Respective potencies of Botox® and Dysport® in a human skin model: A randomized, double‐blind study

Identifieur interne : 002073 ( Main/Exploration ); précédent : 002072; suivant : 002074

Respective potencies of Botox® and Dysport® in a human skin model: A randomized, double‐blind study

Auteurs : Gottfried Kranz [Autriche] ; Dietrich Haubenberger [Autriche] ; Bernhard Voller [Autriche] ; Martin Posch [Autriche] ; Peter Schnider [Autriche] ; Eduard Auff [Autriche] ; Thomas Sycha [Autriche]

Source :

Movement Disorders [ 0885-3185 ] ; 2009-01-30.

RBID : ISTEX:659C85D9163DDE3946E345437095DB5099F7C9D5

Descripteurs français

Pascal (Inist)
- Bontoxilysin, Etude double insu, Homme, Modèle, Pathologie du système nerveux, Peau, Sueur.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Abdomen, Adult, Bontoxilysin, Botulinum Toxins, Type A (administration & dosage), Botulinum Toxins, Type A (pharmacokinetics), Botulinum Toxins, Type A (pharmacology), Diffusion, Dose-Response Relationship, Drug, Double blind study, Double-Blind Method, Female, Hot Temperature, Human, Humans, Injections, Intradermal, Male, Models, Nervous system diseases, Reproducibility of Results, Skin, Skin (drug effects), Sweat, Sweating (drug effects), Young Adult, botulinum toxin A, dose unit ratio, ninhydrin sweat test, respective potencies.
MESH :
- chemical , administration & dosage : Botulinum Toxins, Type A.
- chemical , pharmacokinetics : Botulinum Toxins, Type A.
- chemical , pharmacology : Botulinum Toxins, Type A.
- drug effects : Skin, Sweating.
- Abdomen, Adult, Diffusion, Dose-Response Relationship, Drug, Double-Blind Method, Female, Hot Temperature, Humans, Injections, Intradermal, Male, Reproducibility of Results, Young Adult.

Abstract

Mouse units used to quantify the activity of botulinum A toxin preparations are not equivalent and issues concerning efficacy and safety remain with regard to their respective potencies and diffusion qualities in human tissue. We compared the effects of Botox® (BOT) and Dysport® (DYS) in different doses and dilutions in a human skin model. Eighteen (8 women, 10 men) healthy volunteers, aged 28.4 years ± 5.7 years were injected intradermally with pure saline, BOT and DYS at 16 points in the abdomen in random order and in a double‐blind condition, using two conversion ratios (1:3 and 1:4) and three different dilution schemes. For an objective outcome, the Ninhydrin sweat test was used to compare the anhidrotic areas. Both preparations showed a linear dose and dilution relationship with similar variances of responses for anhidrosis and hypohidrosis, indicating the same reliability of response. The dose equivalence conversion ratios (BOT: DYS) were 1:1.3 for anhidrosis and 1:1.6 for hypohidrosis (1:1.1‐1.5 and 1:1.4‐1.8 95% confidence intervals). The diffusion characteristics of both products were similar. A dose equivalence factor of more than 1:2 (BOT:DYS) is not supported by these objective and reproducible data. © 2008 Movement Disorder Society

Url:

https://api.istex.fr/document/659C85D9163DDE3946E345437095DB5099F7C9D5/fulltext/pdf

DOI: 10.1002/mds.22336

Affiliations:

Le document en format XML

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<term>Adult</term>
<term>Bontoxilysin</term>
<term>Botulinum Toxins, Type A (administration & dosage)</term>
<term>Botulinum Toxins, Type A (pharmacokinetics)</term>
<term>Botulinum Toxins, Type A (pharmacology)</term>
<term>Diffusion</term>
<term>Dose-Response Relationship, Drug</term>
<term>Double blind study</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Hot Temperature</term>
<term>Human</term>
<term>Humans</term>
<term>Injections, Intradermal</term>
<term>Male</term>
<term>Models</term>
<term>Nervous system diseases</term>
<term>Reproducibility of Results</term>
<term>Skin</term>
<term>Skin (drug effects)</term>
<term>Sweat</term>
<term>Sweating (drug effects)</term>
<term>Young Adult</term>
<term>botulinum toxin A</term>
<term>dose unit ratio</term>
<term>ninhydrin sweat test</term>
<term>respective potencies</term>
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<term>Sweating</term>
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<term>Adult</term>
<term>Diffusion</term>
<term>Dose-Response Relationship, Drug</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Hot Temperature</term>
<term>Humans</term>
<term>Injections, Intradermal</term>
<term>Male</term>
<term>Reproducibility of Results</term>
<term>Young Adult</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Bontoxilysin</term>
<term>Etude double insu</term>
<term>Homme</term>
<term>Modèle</term>
<term>Pathologie du   système nerveux</term>
<term>Peau</term>
<term>Sueur</term>
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<front><div type="abstract" xml:lang="en">Mouse units used to quantify the activity of botulinum A toxin preparations are not equivalent and issues concerning efficacy and safety remain with regard to their respective potencies and diffusion qualities in human tissue. We compared the effects of Botox® (BOT) and Dysport® (DYS) in different doses and dilutions in a human skin model. Eighteen (8 women, 10 men) healthy volunteers, aged 28.4 years ± 5.7 years were injected intradermally with pure saline, BOT and DYS at 16 points in the abdomen in random order and in a double‐blind condition, using two conversion ratios (1:3 and 1:4) and three different dilution schemes. For an objective outcome, the Ninhydrin sweat test was used to compare the anhidrotic areas. Both preparations showed a linear dose and dilution relationship with similar variances of responses for anhidrosis and hypohidrosis, indicating the same reliability of response. The dose equivalence conversion ratios (BOT: DYS) were 1:1.3 for anhidrosis and 1:1.6 for hypohidrosis (1:1.1‐1.5 and 1:1.4‐1.8 95% confidence intervals). The diffusion characteristics of both products were similar. A dose equivalence factor of more than 1:2 (BOT:DYS) is not supported by these objective and reproducible data. © 2008 Movement Disorder Society</div>
</front>
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<name sortKey="Posch, Martin" sort="Posch, Martin" uniqKey="Posch M" first="Martin" last="Posch">Martin Posch</name>
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Movement Disorders (revue)

Respective potencies of Botox® and Dysport® in a human skin model: A randomized, double‐blind study

Respective potencies of Botox® and Dysport® in a human skin model: A randomized, double‐blind study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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